Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

BACKGROUND: The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation...

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Autores principales: Broderick, Peter, Bagratuni, Tina, Vijayakrishnan, Jairam, Lubbe, Steven, Chandler, Ian, Houlston, Richard S
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1624846/
https://ncbi.nlm.nih.gov/pubmed/17029639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-243
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