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Human Immunodeficiency Virus Type 1 Vpr Induces the Degradation of the UNG and SMUG Uracil-DNA Glycosylases

The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr has previously been shown to bind to the cellular uracil DNA glycosylase UNG. We show here that the binding of Vpr to UNG and to the related enzyme SMUG induces their proteasomal degradation. UNG and SMUG were found to be encapsid...

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Autori principali: Schröfelbauer, Bärbel, Yu, Qin, Zeitlin, Samantha G., Landau, Nathaniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193627/
https://ncbi.nlm.nih.gov/pubmed/16103149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.10978-10987.2005
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