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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
The Vpr accessory protein of HIV-1 induces a response similar to that of DNA damage. In cells expressing Vpr, the DNA damage sensing kinase, ATR, is activated, resulting in G(2) arrest and apoptosis. In addition, Vpr causes rapid degradation of the uracil-DNA glycosylases UNG2 and SMUG1. Although se...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820720/ https://ncbi.nlm.nih.gov/pubmed/17360488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610167104 |
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