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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1
Monocyte-derived macrophages (MDMs) are an important target for HIV-1 despite SAMHD1, a myeloid restriction factor for which HIV-1 lacks a counteracting accessory protein. The antiviral activity of SAMHD1 is modulated by phosphorylation of T592 by cyclin-dependent kinases (CDK). We show that treatme...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group UK
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841438/ https://ncbi.nlm.nih.gov/pubmed/29515139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22432-4 |
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