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Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung(−/−)Msh2(−/−) mice

Deamination of cytosine (C), 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) occurs spontaneously in mammalian DNA with several hundred deaminations occurring in each cell every day. The resulting potentially mutagenic mispairs of uracil (U), thymine (T) or 5-hydroxymethyluracil (hmU) with g...

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Main Authors: Kemmerich, Kristin, Dingler, Felix A., Rada, Cristina, Neuberger, Michael S.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401444/
https://ncbi.nlm.nih.gov/pubmed/22447450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks259
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