Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

BACKGROUND: The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation...

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Hlavní autoři: Broderick, Peter, Bagratuni, Tina, Vijayakrishnan, Jairam, Lubbe, Steven, Chandler, Ian, Houlston, Richard S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1624846/
https://ncbi.nlm.nih.gov/pubmed/17029639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-243
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