Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication

Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions and is known to...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Bjørås, Karine Ø., Sousa, Mirta M. L., Sharma, Animesh, Fonseca, Davi M., Søgaard, Caroline K., Bjørås, Magnar, Otterlei, Marit
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737410/
https://ncbi.nlm.nih.gov/pubmed/28575236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx476
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