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Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α

The hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α) have extensive structural homology and have been identified as key transcription factors responsible for gene expression in response to hypoxia. They play critical roles not only in normal development, but also in tumor progression. Here we r...

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Detalhes bibliográficos
Main Authors: Park, Sang-ki, Dadak, Agnes M., Haase, Volker H., Fontana, Lucrezia, Giaccia, Amato J., Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC162224/
https://ncbi.nlm.nih.gov/pubmed/12832481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4959-4971.2003
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