NF-κB1 p105 Negatively Regulates TPL-2 MEK Kinase Activity

Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus. This mutation also weakens the interaction of TPL-2 with NF-κB1 p105 in vitro, although it is unclear whether this is important for the activation of TPL-2 oncogenicity. It is demonstrated here t...

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Main Authors: Beinke, S., Deka, J., Lang, V., Belich, M. P., Walker, P. A., Howell, S., Smerdon, S. J., Gamblin, S. J., Ley, S. C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC162207/
https://ncbi.nlm.nih.gov/pubmed/12832462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4739-4752.2003
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