Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by IκB Kinase-Induced Proteolysis of NF-κB1 p105

The MEK kinase TPL-2 (also known as Cot) is required for lipopolysaccharide (LPS) activation of the extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase cascade in macrophages and consequent upregulation of genes involved in innate immune responses. In resting cells, TP...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Beinke, S., Robinson, M. J., Hugunin, M., Ley, S. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522219/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15485931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.21.9658-9667.2004
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