Bradyzide, a potent non-peptide B(2) bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia

1. Bradyzide is from a novel class of rodent-selective non-peptide B(2) bradykinin antagonists (1-(2-Nitrophenyl)thiosemicarbazides). 2. Bradyzide has high affinity for the rodent B(2) receptor, displacing [(3)H]-bradykinin binding in NG108-15 cells and in Cos-7 cells expressing the rat receptor wit...

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Detalhes bibliográficos
Main Authors: Burgess, Gillian M, Perkins, Martin N, Rang, Humphrey P, Campbell, Elizabeth A, Brown, Michael C, McIntyre, Peter, Urban, Laszlo, Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Wrigglesworth, Roger, Lee, Wai, Davis, Clare, Phagoo, Steve B, Davis, Andrew J, Phillips, Elsa, Drake, Gillian S, Hughes, Glyn A, Dunstan, Andrew, Bloomfield, Graham C
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1621130/
https://ncbi.nlm.nih.gov/pubmed/10694205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703012
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