Metallopeptidase inhibition potentiates bradykinin-induced hyperalgesia

The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15),...

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Hlavní autoři: Gomez, Ruben, Por, Elaine D., Berg, Kelly A., Clarke, William P., Glucksman, Marc J., Jeske, Nathaniel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114295/
https://ncbi.nlm.nih.gov/pubmed/21458920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.02.044
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