Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood : brain, 1 : <0.05), and was therefore administered intravenously in chronic constriction injury (CCI)- and sham-ope...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Sharp, Caroline J, Reeve, Alison J, Collins, Sue D, Martindale, Jo C, Summerfield, Scott G, Sargent, Becky S, Bate, Simon T, Chessell, Iain P
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2006
Sujets:
Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617075/
https://ncbi.nlm.nih.gov/pubmed/16770326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706790
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