Interspecies pharmacokinetics and in vitro metabolism of SQ109

1. This study aimed at characterizing the interspecies absorption, distribution, metabolism and elimination (ADME) profile of N-geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109), a new diamine-based antitubercular drug. 2. Single doses of SQ109 were administered (intravenously (i.v.) and per os (p....

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Autores principales: Jia, Lee, Noker, Patricia E, Coward, Lori, Gorman, Gregory S, Protopopova, Marina, Tomaszewski, Joseph E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2006
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1616981/
https://ncbi.nlm.nih.gov/pubmed/16432511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706650
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