Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

The causes of cerebral accumulation of amyloid β-protein (Aβ) in most cases of Alzheimer’s disease (AD) remain unknown. We recently found that homozygous deletion of the insulin-degrading enzyme (IDE) gene in mice results in an early and marked elevation of cerebral Aβ. Both genetic linkage and alle...

Full description

Saved in:
Bibliographic Details
Main Authors: Farris, Wesley, Mansourian, Stefan, Leissring, Malcolm A., Eckman, Elizabeth A., Bertram, Lars, Eckman, Christopher B., Tanzi, Rudolph E., Selkoe, Dennis J.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2004
Subjects:
Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615329/
https://ncbi.nlm.nih.gov/pubmed/15039230
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items