Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro

Islet amyloid deposition in human type 2 diabetes results in β-cell loss. These amyloid deposits contain the unique amyloidogenic peptide human islet amyloid polypeptide (hIAPP), which is also a known substrate of the protease insulin-degrading enzyme (IDE). Whereas IDE inhibition has recently been...

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Pubblicato in:Endocrinology
Autori principali: Hogan, Meghan F., Meier, Daniel T., Zraika, Sakeneh, Templin, Andrew T., Mellati, Mahnaz, Hull, Rebecca L., Leissring, Malcolm A., Kahn, Steven E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007890/
https://ncbi.nlm.nih.gov/pubmed/27404391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1410
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