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Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity
Deposition of human islet amyloid polypeptide (hIAPP, also known as amylin) as islet amyloid is a characteristic feature of the pancreas in type 2 diabetes, contributing to increased β-cell apoptosis and reduced β-cell mass. Matrix metalloproteinase-9 (MMP-9) is active in islets and cleaves hIAPP. W...
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Udgivet i: | J Biol Chem |
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Main Authors: | , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
American Society for Biochemistry and Molecular Biology
2015
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4683269/ https://ncbi.nlm.nih.gov/pubmed/26483547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676692 |
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