Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity

Deposition of human islet amyloid polypeptide (hIAPP, also known as amylin) as islet amyloid is a characteristic feature of the pancreas in type 2 diabetes, contributing to increased β-cell apoptosis and reduced β-cell mass. Matrix metalloproteinase-9 (MMP-9) is active in islets and cleaves hIAPP. W...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Meier, Daniel T., Tu, Ling-Hsien, Zraika, Sakeneh, Hogan, Meghan F., Templin, Andrew T., Hull, Rebecca L., Raleigh, Daniel P., Kahn, Steven E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683269/
https://ncbi.nlm.nih.gov/pubmed/26483547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676692
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