Loss of perlecan heparan sulfate glycosaminoglycans lowers body weight and decreases islet amyloid deposition in human islet amyloid polypeptide transgenic mice

Islet amyloid is a pathologic feature of type 2 diabetes (T2D) that is associated with β-cell loss and dysfunction. These amyloid deposits form via aggregation of the β-cell secretory product islet amyloid polypeptide (IAPP) and contain other molecules including the heparan sulfate proteoglycan perl...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Templin, Andrew T, Mellati, Mahnaz, Soininen, Raija, Hogan, Meghan F, Esser, Nathalie, Castillo, J Josh, Zraika, Sakeneh, Kahn, Steven E, Hull, Rebecca L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908817/
https://ncbi.nlm.nih.gov/pubmed/31769491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzz041
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