Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

The causes of cerebral accumulation of amyloid β-protein (Aβ) in most cases of Alzheimer’s disease (AD) remain unknown. We recently found that homozygous deletion of the insulin-degrading enzyme (IDE) gene in mice results in an early and marked elevation of cerebral Aβ. Both genetic linkage and alle...

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Detalhes bibliográficos
Main Authors: Farris, Wesley, Mansourian, Stefan, Leissring, Malcolm A., Eckman, Elizabeth A., Bertram, Lars, Eckman, Christopher B., Tanzi, Rudolph E., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2004
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615329/
https://ncbi.nlm.nih.gov/pubmed/15039230
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