Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition

Microglia accumulation at the site of amyloid plaques is a strong indication that microglia play a major role in Alzheimer’s disease pathogenesis. However, how microglia affect amyloid-β peptide (Aβ) deposition remains poorly understood. To address this question, we developed a novel bigenic mouse t...

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Detalhes bibliográficos
Main Authors: Yamamoto, Masaru, Horiba, Masahide, Buescher, James L., Huang, DeReng, Gendelman, Howard E., Ransohoff, Richard M., Ikezu, Tsuneya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606401/
https://ncbi.nlm.nih.gov/pubmed/15855647
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