Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease

Here, we investigate the involvement of caveolins in the pathophysiology of Alzheimer’s disease (AD). We show dramatic upregulation of caveolin-3 immunoreactivity in astroglial cells surrounding senile plaques in brain tissue sections from authentic AD patients and an established transgenic mouse mo...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nishiyama, Kazutoshi, Trapp, Bruce D., Ikezu, Tsuneya, Ransohoff, Richard M., Tomita, Taisuke, Iwatsubo, Takeshi, Kanazawa, Ichiro, Hsiao, Karen K., Lisanti, Michael P., Okamoto, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782816/
https://ncbi.nlm.nih.gov/pubmed/10414982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-15-06538.1999
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