Establishment of a Diabetic Mouse Model with Progressive Diabetic Nephropathy

Although diabetic animal models exist, no single animal model develops renal changes identical to those seen in humans. Here we show that transgenic mice that overexpress inducible cAMP early repressor (ICER Iγ) in pancreatic β cells are a good model to study the pathogenesis of diabetic nephropathy...

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Autors principals: Inada, Akari, Nagai, Kojiro, Arai, Hidenori, Miyazaki, Jun-ichi, Nomura, Keiko, Kanamori, Hiroshi, Toyokuni, Shinya, Yamada, Yuichiro, Bonner-Weir, Susan, Weir, Gordon C., Fukatsu, Atsushi, Seino, Yutaka
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2005
Matèries:
Original Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603579/
https://ncbi.nlm.nih.gov/pubmed/16049320
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