Establishment of a Diabetic Mouse Model with Progressive Diabetic Nephropathy

Although diabetic animal models exist, no single animal model develops renal changes identical to those seen in humans. Here we show that transgenic mice that overexpress inducible cAMP early repressor (ICER Iγ) in pancreatic β cells are a good model to study the pathogenesis of diabetic nephropathy...

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Bibliographic Details
Main Authors: Inada, Akari, Nagai, Kojiro, Arai, Hidenori, Miyazaki, Jun-ichi, Nomura, Keiko, Kanamori, Hiroshi, Toyokuni, Shinya, Yamada, Yuichiro, Bonner-Weir, Susan, Weir, Gordon C., Fukatsu, Atsushi, Seino, Yutaka
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603579/
https://ncbi.nlm.nih.gov/pubmed/16049320
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