Increased DNA Methyltransferase 1 (DNMT1) Protein Expression Correlates Significantly with Poorer Tumor Differentiation and Frequent DNA Hypermethylation of Multiple CpG Islands in Gastric Cancers

We evaluated the significance of aberrant DNA methyltransferase 1 (DNMT1) protein expression during gastric carcinogenesis. The protein expression of DNMT1, Muc2, human gastric mucin, E-cadherin, and proliferating cell nuclear antigen was examined immunohistochemically in gastric cancers and corresp...

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Main Authors: Etoh, Tsuyoshi, Kanai, Yae, Ushijima, Saori, Nakagawa, Tohru, Nakanishi, Yukihiro, Sasako, Mitsuru, Kitano, Seigo, Hirohashi, Setsuo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602280/
https://ncbi.nlm.nih.gov/pubmed/14742272
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