Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

DNA hypomethylation on pericentromeric satellite regions is an early and frequent event associated with heterochromatin instability during human hepatocarcinogenesis. A DNA methyltransferase, DNMT3b, is required for methylation on pericentromeric satellite regions during mouse development. To clarif...

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Detalhes bibliográficos
Main Authors: Saito, Yoshimasa, Kanai, Yae, Sakamoto, Michiie, Saito, Hidetsugu, Ishii, Hiromasa, Hirohashi, Setsuo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126624/
https://ncbi.nlm.nih.gov/pubmed/12110732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152121799
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