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Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

DNA hypomethylation on pericentromeric satellite regions is an early and frequent event associated with heterochromatin instability during human hepatocarcinogenesis. A DNA methyltransferase, DNMT3b, is required for methylation on pericentromeric satellite regions during mouse development. To clarif...

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Bibliografski detalji
Glavni autori: Saito, Yoshimasa, Kanai, Yae, Sakamoto, Michiie, Saito, Hidetsugu, Ishii, Hiromasa, Hirohashi, Setsuo
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC126624/
https://ncbi.nlm.nih.gov/pubmed/12110732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152121799
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