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Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function
Dilated cardiomyopathy (DCM) leads to heart failure, a leading cause of death in industrialized nations. Approximately 30% of DCM cases are genetic in origin, with some resulting from point mutations in cardiac myosin, the molecular motor of the heart. The effects of these mutations on myosin's...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599993/ https://ncbi.nlm.nih.gov/pubmed/16983074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606383103 |
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