Role of Titin Missense Variants in Dilated Cardiomyopathy

BACKGROUND: The titin gene (TTN) encodes the largest human protein, which plays a central role in sarcomere organization and passive myocyte stiffness. TTN truncating mutations cause dilated cardiomyopathy (DCM); however, the role of TTN missense variants in DCM has been difficult to elucidate becau...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Begay, Rene L., Graw, Sharon, Sinagra, Gianfranco, Merlo, Marco, Slavov, Dobromir, Gowan, Katherine, Jones, Kenneth L., Barbati, Giulia, Spezzacatene, Anita, Brun, Francesca, Di Lenarda, Andrea, Smith, John E., Granzier, Henk L., Mestroni, Luisa, Taylor, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845231/
https://ncbi.nlm.nih.gov/pubmed/26567375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002645
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