Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function

Dilated cardiomyopathy (DCM) leads to heart failure, a leading cause of death in industrialized nations. Approximately 30% of DCM cases are genetic in origin, with some resulting from point mutations in cardiac myosin, the molecular motor of the heart. The effects of these mutations on myosin's...

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Main Authors: Schmitt, Joachim P., Debold, Edward P., Ahmad, Ferhaan, Armstrong, Amy, Frederico, Andrea, Conner, David A., Mende, Ulrike, Lohse, Martin J., Warshaw, David, Seidman, Christine E., Seidman, J. G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599993/
https://ncbi.nlm.nih.gov/pubmed/16983074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606383103
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