Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation

Sphingosine kinase (Sphk) enzymes are important in intracellular sphingolipid metabolism as well as in the biosynthesis of sphingosine 1-phosphate (S1P), an extracellular lipid mediator. Here, we show that Sphk1 is expressed and is required for small intestinal tumor cell proliferation in Apc(Min/+)...

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Autors principals: Kohno, Masataka, Momoi, Michiko, Oo, Myat Lin, Paik, Ji-Hye, Lee, Yong-Moon, Venkataraman, Krishnan, Ai, Youxi, Ristimaki, Ari P., Fyrst, Henrik, Sano, Hajime, Rosenberg, Daniel, Saba, Julie D., Proia, Richard L., Hla, Timothy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592880/
https://ncbi.nlm.nih.gov/pubmed/16980623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02341-05
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