Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1

HER4 expression in human breast cancers correlates with a positive prognosis. While heregulin inhibits the growth of HER4-positive breast cancer cells, it does so by undefined mechanisms. We demonstrate that heregulin-induced HER4 activity inhibits cell proliferation and delays G(2)/M progression of...

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Main Authors: Muraoka-Cook, Rebecca S., Caskey, Laura S., Sandahl, Melissa A., Hunter, Debra M., Husted, Carty, Strunk, Karen E., Sartor, Carolyn I., Rearick, William A., McCall, Wesley, Sgagias, Magdalene K., Cowan, Kenneth H., Earp, H. Shelton
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592831/
https://ncbi.nlm.nih.gov/pubmed/16914727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01950-05
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