The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis

It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactiv...

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Bibliographic Details
Main Authors: Lee, Jean-pyo, Palfrey, H. Clive, Bindokas, Vytautas P., Ghadge, Ghanashyam D., Ma, Li, Miller, Richard J., Roos, Raymond P.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15928/
https://ncbi.nlm.nih.gov/pubmed/10077670
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