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Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis

There is emerging evidence for the existence of secretory pathways for superoxide dismutase (SOD1) mutants linked to amyotrophic lateral sclerosis (ALS) and for neurotoxicity of extracellular mutant SOD1. This evidence led us to test immunization protocols aiming to reduce the burden of extracellula...

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Détails bibliographiques
Auteurs principaux: Urushitani, Makoto, Ezzi, Samer Abou, Julien, Jean-Pierre
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1790867/
https://ncbi.nlm.nih.gov/pubmed/17277077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606201104
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