Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset progressive paralytic disease characterized by loss of motor neurons, and cause an ALS-like disease when expressed in mice. Recent data have suggested that motor neuron degeneration results from toxic...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Jaarsma, Dick, Teuling, Eva, Haasdijk, Elize D., De Zeeuw, Chris I., Hoogenraad, Casper C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2008
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671838/
https://ncbi.nlm.nih.gov/pubmed/18305242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5258-07.2008
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