Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment

BACKGROUND: Protein aggregation and the formation of intracellular inclusions are a central feature of many neurodegenerative disorders, but precise knowledge about their pathogenic role is lacking in most instances. Here we have characterized inclusions formed in transgenic mice carrying the P56S m...

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Detalhes bibliográficos
Main Authors: Kuijpers, Marijn, van Dis, Vera, Haasdijk, Elize D, Harterink, Martin, Vocking, Karin, Post, Jan A, Scheper, Wiep, Hoogenraad, Casper C, Jaarsma, Dick
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893532/
https://ncbi.nlm.nih.gov/pubmed/24252306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-24
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