Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons

BACKGROUND: Fragmentation of stacked cisterns of the Golgi apparatus into dispersed smaller elements is a feature associated with degeneration of neurons in amyotrophic lateral sclerosis (ALS) and some other neurodegenerative disorders. However, the role of Golgi fragmentation in motor neuron degene...

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Detalhes bibliográficos
Main Authors: van Dis, Vera, Kuijpers, Marijn, Haasdijk, Elize D, Teuling, Eva, Oakes, Scott A, Hoogenraad, Casper C, Jaarsma, Dick
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023628/
https://ncbi.nlm.nih.gov/pubmed/24708899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-38
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