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Hot-spot mimicry of a cytokine receptor by a small molecule
Protein–protein complexes remain enticing, but extremely challenging, targets for small-molecule drug discovery. In a rare example described earlier, a high-affinity small molecule, SP4206 (K(d) ≈ 70 nM), was found to block binding of the IL-2α receptor (IL-2Rα) to IL-2 (K(d) ≈ 10 nM). Recently, the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592646/ https://ncbi.nlm.nih.gov/pubmed/17032757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607058103 |
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