लोड हो रहा है...
Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein–Protein Interaction
Protein–protein interactions drive every aspect of cell signaling, yet only a few small-molecule inhibitors of these interactions exist. Despite our ability to identify critical residues known as hot spots, little is known about how to effectively engage them to disrupt protein–protein interactions....
में बचाया:
| में प्रकाशित: | Biochemistry |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5812370/ https://ncbi.nlm.nih.gov/pubmed/28186725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01039 |
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