Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor protein...

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Main Authors: Baba, Masaya, Hong, Seung-Beom, Sharma, Nirmala, Warren, Michelle B., Nickerson, Michael L., Iwamatsu, Akihiro, Esposito, Dominic, Gillette, William K., Hopkins, Ralph F., Hartley, James L., Furihata, Mutsuo, Oishi, Shinya, Zhen, Wei, Burke, Terrence R., Linehan, W. Marston, Schmidt, Laura S., Zbar, Berton
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592464/
https://ncbi.nlm.nih.gov/pubmed/17028174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603781103
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