Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-cadherin, LKB1 and AMPK

Spontaneous pneumothoraces due to lung cyst rupture afflict patients with the rare disease Birt-Hogg-Dubé (BHD) syndrome caused by mutations of the tumor suppressor gene folliculin (FLCN) by unknown mechanism. BHD lungs exhibit increased alveolar epithelial cell apoptosis. We show that Flcn deletion...

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Autors principals: Goncharova, Elena A., Goncharov, Dmitry A., James, Melane L., Atochina-Vasserman, Elena N., Stepanova, Victoria, Hong, Seung-Beom, Li, Hua, Gonzales, Linda, Baba, Masaya, Linehan, W. Marston, Gow, Andrew J., Margulies, Susan, Guttentag, Susan, Schmidt, Laura S., Krymskaya, Vera P.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034569/
https://ncbi.nlm.nih.gov/pubmed/24726356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.025
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