The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized by cutaneous fibrofolliculomas, pulmonary cysts, and kidney malignancies. Affected individuals carry germ line mutations in folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney tumors...

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Autores principales: Baba, Masaya, Keller, Jonathan R., Sun, Hong-Wei, Resch, Wolfgang, Kuchen, Stefan, Suh, Hyung Chan, Hasumi, Hisashi, Hasumi, Yukiko, Kieffer-Kwon, Kyong-Rim, Gonzalez, Carme Gallego, Hughes, Robert M., Klein, Mara E., Oh, Hyoungbin F., Bible, Paul, Southon, Eileen, Tessarollo, Lino, Schmidt, Laura S., Linehan, W. Marston, Casellas, Rafael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418720/
https://ncbi.nlm.nih.gov/pubmed/22709692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-410407
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