A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3α is essential for agonist-induced phosphorylation, desensitization and internalization

1. Two isoforms of the rat prostaglandin E(2) receptor, rEP3α-R and rEP3β-R, differ only in their C-terminal domain. To analyze the function of the rEP3-R C-terminal domain in agonist induced desensitization, a cluster of Ser/Thr residues in the C-terminal domain of the rEP3α-R was mutated to Ala an...

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Bibliographic Details
Main Authors: Neuschäfer-Rube, Frank, Hermosilla, Ricardo, Kuna, Manuela, Pathe-Neuschäfer-Rube, Andrea, Schülein, Ralf, Püschel, Gerhard Paul
Format: Artigo
Language:Inglês
Published: 2005
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576232/
https://ncbi.nlm.nih.gov/pubmed/15937517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706282
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