Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.

hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a G(s)-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linke...

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Detalhes bibliográficos
Main Authors: Neuschäfer-Rube, Frank, Hermosilla, Ricardo, Rehwald, Mathias, Rönnstrand, Lars, Schülein, Ralf, Wernstedt, Christer, Püschel, Gerhard Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224101/
https://ncbi.nlm.nih.gov/pubmed/14709160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031820
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