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Role of PDE4 in superoxide anion generation through p44/42(MAPK) regulation: a cAMP and a PKA-independent mechanism
1. We investigated the generation of reactive oxygen species (ROS) from bronchoalveolar lavage (BAL) cells of either control or LPS-exposed rats and the effects of PDE4 inhibitors on ROS production. 2. The PDE4 inhibitors, rolipram and Ariflo (cilomilast, SB 207499) dose-dependently (0.1–10 μM) inhi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575336/ https://ncbi.nlm.nih.gov/pubmed/15313882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705927 |
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