Role of PDE4 in superoxide anion generation through p44/42(MAPK) regulation: a cAMP and a PKA-independent mechanism

1. We investigated the generation of reactive oxygen species (ROS) from bronchoalveolar lavage (BAL) cells of either control or LPS-exposed rats and the effects of PDE4 inhibitors on ROS production. 2. The PDE4 inhibitors, rolipram and Ariflo (cilomilast, SB 207499) dose-dependently (0.1–10 μM) inhi...

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Main Authors: Jacob, Claire, Szilagyi, Corinne, Allen, Janet M, Bertrand, Claude, Lagente, Vincent
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575336/
https://ncbi.nlm.nih.gov/pubmed/15313882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705927
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