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Interaction of a novel dihydropyridine K(+) channel opener, A-312110, with recombinant sulphonylurea receptors and K(ATP) channels: comparison with the cyanoguanidine P1075

1. ATP-sensitive K(+) channels (K(ATP) channels) are composed of pore-forming subunits (Kir6.x) and of regulatory subunits, the sulphonylurea receptors (SURx). Synthetic openers of K(ATP) channels form a chemically heterogeneous class of compounds that are of interest in several therapeutic areas. W...

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Bibliografiske detaljer
Main Authors: Felsch, Holger, Lange, Ulf, Hambrock, Annette, Löffler-Walz, Cornelia, Russ, Ulrich, Carroll, William A, Gopalakrishnan, Murali, Quast, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574886/
https://ncbi.nlm.nih.gov/pubmed/15023854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705718
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