The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2

1. ATP-sensitive K(+) channels (K(ATP) channels) are tetradimeric complexes of inwardly rectifying K(+) channels (Kir6.x) and sulphonylurea receptors (SURs). The SURs SUR2A (cardiac) and SUR2B (smooth muscle) differ only in the last 42 amino acids. In SUR2B, the mutation Y1206S, located at intracell...

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Detalhes bibliográficos
Main Authors: Stephan, Damian, Stauß, Eva, Lange, Ulf, Felsch, Holger, Löffler-Walz, Cornelia, Hambrock, Annette, Russ, Ulrich, Quast, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576091/
https://ncbi.nlm.nih.gov/pubmed/15711591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706142
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