Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides

1. ATP-sensitive K(+) channels are composed of pore-forming subunits Kir6.2 and of sulphonylurea receptors (SURs); the latter are the target of the hypoglycaemic sulphonylureas like glibenclamide. Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SU...

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Hlavní autoři: Hambrock, Annette, Löffler-Walz, Cornelia, Quast, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573429/
https://ncbi.nlm.nih.gov/pubmed/12145099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704801
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