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Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides
1. ATP-sensitive K(+) channels are composed of pore-forming subunits Kir6.2 and of sulphonylurea receptors (SURs); the latter are the target of the hypoglycaemic sulphonylureas like glibenclamide. Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SU...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573429/ https://ncbi.nlm.nih.gov/pubmed/12145099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704801 |
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