Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies
Random mutagenesis and selection using phage or cell surface display provides an efficient method for affinity maturation of single chain Fv (scFv) antibodies, thereby improving function in various applications. To investigate the effects of mutation frequency on affinity maturation, error-prone PCR...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.030527597 |
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