Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies
Random mutagenesis and selection using phage or cell surface display provides an efficient method for affinity maturation of single chain Fv (scFv) antibodies, thereby improving function in various applications. To investigate the effects of mutation frequency on affinity maturation, error-prone PCR...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.030527597 |
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